姓名：金辉
职称：讲师、硕士生导师
电话：024-89385213
电子邮件：hjin@syuct.edu.cn
教育背景：
2007.10——2011.06 大连医科大学，药学专业学士学位
2011.09——2014.07 沈阳药科大学，药物化学专业硕士学位
2015.03——2018.08 韩国成均馆大学，有机化学专业博士学位
工作经历：
2014.09——2015.02 韩国成均馆大学，化学系，研究实习员
2018.12——至今 betway中国西汉姆联官网，讲师
研究方向：
1. 有机合成方法学（不对称催化，绿色化学）
2. 功能分子（新药，荧光分子）合成研究
代表性成果：（论文、专利等）
1. Jubao Zhou, Siyun Wang, Hu Shi, Hui Jin,* and Lixin Zhang* Ligand-Free Silver Fluoride-Promoted (3 + 2) Annulation of Oxaziridines and α‑Isocyanoacetates: A Diastereoselective Route to cis-Imidazolines. J. Org. Chem. 2025, 90, 8794−8799.
2. Chen Zhu,‡ Jing Zhang,‡ Jiaxin Yang, Xinxin Li, Xinyu Wang, Hu Shi, Hui Jin,* and Lixin Zhang*. Ketenes as dienophiles in aza-Diels–Alder reactions with dicyanohydrazones for accessing pyridazin-3(2H)-ones. Org. Biomol. Chem. 2025, 23, 6220-6224.
3. Jinfeng Zhang, Chen Zhu, Hu Shi, Hui Jin,* and Lixin Zhang*. N‑Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2‑Pyrones. J. Org. Chem. 2025, 90, 6094−6101.
4. Tianxing Li, Xinxin Li, Jinfeng Zhang, Hui Jin* and Lixin Zhang* Enantioselective Synthesis of 3,4-Dihydropyranones via Low-Loading Squaramide Catalysis “On Water” Adv. Synth. Catal. 2025, 367, e70141.
5. Xinxin Li,† Jun Yang,† Tianxing Li, Chen Zhu, Hui Jin,* and Lixin Zhang* ‘On Water’ Synthesis of Indolyl-Substituted Benzo[b]carbazoles via LiCl-Promoted HBF4-Catalyzed Annulation of ortho-Formylaryl Ketones with Indoles. Synthesis 2025, 57, 2115–2123.
6. Chen Zhu, Jinfeng Zhang, Tianxing Li, Hui Jin* and Lixin Zhang* Development of aryl 2-pyridinone-fused 2-pyrimidone as a TICT-based turn-off fluorescent probe for ultra-low pH sensing. Dyes and Pigments, 2025, 239, 112795.
7. Jun Yang, Tianxing Li, Hui Jin,* and Lixin Zhang* Efficient Synthesis of Indolyl Benzo[b]carbazoles via Surfactant-Type Brønsted Acid-Catalyzed Three-Component Cyclization of Ortho-Formylarylketones with Indoles. Eur. J. Org. Chem. 2025, e202401466.
8. Jun Yang,† Jianyu Zhang,† Tianxing Li, Yunting Liu, Hui Jin,* Do Hyun Ryu* and Lixin Zhang* Lithium Chloride-Promoted Brønsted Acid-Catalyzed Friedel-Crafts Reaction of Indoles with Aldehydes and Ketones "on Water" Adv. Synth. Catal. 2025, 367, e202401542.
9. Jian Liu, Bingfu Wang, Tianxing Li, Hui Jin,* and Lixin Zhang,* Proline-derived dichlorophenyl-substituted urea as catalyst for “on-water” asymmetric addition reactions of oxoindoles to nitroolefins. Tetrahedron Lett. 2024, 143,155117.
10. Zeyao Ji, Xiaochen Wang, Bingfu Wang, Zhen Shan, Hui Jin,* and Lixin Zhang*On-off Pulsed Ultrasound Promote Asymmetric Noncovalent Organoatalysis “on Water”: An Investigation in Michael Addition and Diels-Alder Reactions. Adv. Synth. Catal. 2024, 366（14）, 3194-3202.
11. Bingfu Wang, Jian Liu, Hui Jin,* and Lixin Zhang,* Organocatalytic Enantioselective Synthesis of Nitrocyclopropanes Bearing a Thioester Group and Three Stereogenic Centers. Adv. Synth. Catal. 2024, 366（12）, 2742-2748.
12. Bingfu Wang, Jian Liu, Tianxing Li, Hui Jin,* and Lixin Zhang,*.Asymmetric synthesis of (R)-baclofen and (3S,4S)-tetflupyrolimet via “on water” organocatalytic addition reactions: a tip on catalysts screening Org. Biomol. Chem. 2024, 22, 1146-1151.
13. Chen Zhu, Jubao Zhou, Xinxin Li, Xinyu Wang, Hui Jin*, Lixin Zhang* “Clip-cycle” synthesis of 2-pyridazinones bearing enaminonitrile moiety from thioesters and dicyanohydrazones. Tetrahedron Lett. 2024, 135, 154905.
14. Bingfu Wang, Tianxing Li, Jian Liu, Shuo Wang, Hu Shi, Hui Jin,* Do Hyun Ryu*and Lixin Zhang,*. Pentafluorophenyl-Substituted Proline-Derived Chiral Urea for“On Water” Asymmetric Hydrogen-Bonding Catalysis Adv. Synth. Catal. 2023, 365, 4155– 4162.
15. Chen Zhu, Jubao Zhou, Tianxing Li, Jiaxin Yang, Hui Jin,* and Lixin Zhang*. Access to 2-pyridinones comprising enaminonitriles via AgOAc promoted cascade reactions of thioesters with aminomethylene malononitriles. Org. Biomol. Chem. 2023, 21, 6881–6885.
16. Liying Chen, Huiming Di, Jian Liu, Jinfeng Zhang, Bingfu Wang, Hui Jin,* and Lixin Zhang*. Access to functionalized 2-pyrones through cascade reactions of α-halothioesters involving DBU-derived ammonium ylides. Org. Biomol. Chem. 2023, 21, 3756-3760.
17. Xiaochen Wang, Zeyao Ji, Jian Liu, Bingfu Wang, Hui Jin,* and Lixin Zhang*. Advances in Organocatalytic Asymmetric Reactions Involving Thioesters. Acta Chimica Sinica, 2023, 81, 64-83.
18. Yunting Liu, Jing Zhang, Jianyu Zhang, Hongyan Pei, Xuegui Liu, Hui Jin*, Do Hyun Ryu*, Lixin Zhang*, Strecker Reactions of Formaldehyde with TMSCN, Catalyzed by TBAF and Formic Acid: N-Monocyanomethylation of Primary Amines. Adv. Synth. Catal., 2023, 365, 2-7.
19. Xinyue Yang, Yanrong Ma, Huiming Di, Xiaochen Wang, Hui Jin*, Do Hyun Ryu*, Lixin Zhang*. A Mild Method for Access to α-Substituted Dithiomalonates through C-Thiocarbonylation of Thioester: Synthesis of Mesoionic Insecticides. Adv. Synth. Catal., 2021, 363, 3201-3206.
20. Daeil Bae, Juyeol Lee, Hui Jin*, Do Hyun Ryu*. Bifunctional Urea/Hg(OAc)2-Mediated Synthesis of 4-Aryl-6-oxycarbonyl-2-pyrones and 2-Pyridones from Dithiomalonate and β,γ-Unsaturated α-Keto Esters. J. Org. Chem., 2021, 86, 6001-6014.
21. Huiming Di, Yunting Liu, Yanrong Ma, Xinyue Yang, Hui Jin*, Lixin Zhang*. Recent Advances in Organocatalytic Asymmetric Synthesis of 3,4-Dihydropyran-2-ones and 3,4-Dihydropyridin-2-ones. Chin. J. Org. Chem., 2021, 41, 2228-2248.
22. Hui Jin, Juyeol Lee, Hu Shi, Jin Yong Lee, Eun Jeong Yoo, Choong Eui Song, and Do Hyun Ryu*. Bioinspired Synthesis of Chiral 3,4-Dihydropyranones via S-to-O Acyl-Transfer Reactions. Org. Lett. 2018, 20, 1584-1588.
23. Hui Jin, Soo Min Cho, Juyeol Lee, and Do Hyun Ryu*. Role of Configuration at C6 in Catalytic Activity of l-Proline-Derived Bifunctional Organocatalysts. Org. Lett. 2017, 19, 2434-2437.
24. Hui Jin, Soo Min Cho, Geum-Sook Hwang, Do Hyun Ryu. Construction of 3,4-Dihydrocoumarin Derivatives with Adjacent Quaternary and Tertiary Stereocenters: Organocatalytic Asymmetric Michael Addition of 2-Oxochroman-3-carboxylate Esters to trans - β -Nitroolefins. Adv. Synth. Catal., 2017, 359, 163-167.
25. Hui Jin, Seung Tae Kim, Geum-Sook Hwang*, and Do Hyun Ryu*. L-Proline Derived Bifunctional Organocatalysts: Enantioselective Michael Addition of Dithiomalonates to trans-β-Nitroolefins. J. Org. Chem., 2016, 81, 3263-3274.
代表性项目：
1.betway中国西汉姆联官网“优青”托举计划项目“邻位“双手性-双功能”有机催化剂的设计、合成及在硫酯活化中的催化研究”(2022YQ009, 2023.05 - 2028.05), 在研, 主持
2.辽宁省教育厅科学研究经费项目青年项目 “基于脯氨酸的α-单芳基高效叔胺-氢键供体催化剂的设计合成及其性能研究”( LQ2020025, 2020.09 - 2022.12), 结题, 主持
3.辽宁省科技厅自然科学基金联合基金面上资助计划项目“有机催化α-取代非对称丙二酸二硫酯构建季碳中心反应研究”(2023-MSLH-274, 2023.12 - 2025.11), 在研, 主持
4.辽宁省教育厅面上项目 “超声辅助“水上”氢键催化硫酯构建季碳中心反应研究”(LJ212510149012， 2025.07 - 2027.07),在研，主持
