姓名：李丹琦
职称：副教授、硕士生导师
电话：024-89385213
电子邮件：lidanqi@yeah.net
教育背景：
2006.09—2011.07 辽宁中医药大学，中药学（英语班）学士学位
2011.09—2013.07 沈阳药科大学，天然药物化学专业硕士学位
2013.00—2016.07 沈阳药科大学，天然药物化学专业博士学位
工作经历：
2016.09—2022.12 betway中国西汉姆联官网，讲师
2023.01—至今 betway中国西汉姆联官网，副教授
研究方向：
主要从事天然产物结构鉴定与药理活性研究，致力于运用计算机辅助药物设计、网络药理学等先进技术，发掘具有潜力的新先导化合物。同时，结合基因组学与蛋白组学方法，系统开展先导化合物的功能机制探索、天然活性物质分子作用靶点的识别与验证。
代表性成果：（论文、专利等）
1. Fang He, Yongdan Guo, Xin Shen, Lingzhi Li, Danqi Li*, Xuegui Liu*, Pinyi Gao*. Design and synthesis three novel series of derivatives using natural acetylcholinesterase inhibitor-RLMS as template and in vitro, in vivo and in silico activities verification. European Journal of Medicinal Chemistry, 2025, 286, 117309.
2. Ke Zhou, Xingyue Zhang, Xuegui Liu*, Danqi Li*, Pinyi Gao*, Structural features of polysaccharides from Physalis pubescens L. stem, and their neuroprotective effects through Keap1-Nrf2/HO-1 pathway and anti-aging activities. International Journal of Biological Macromolecules, 2025, 329, 147747.
3. Yuxin Tan, Lang Qiu, Danqi Li*, Xuegui Liu*, Pinyi Gao*. Structural elucidation, antioxidant and neuroprotectivefeatures of Physalis pubescens L. polysaccharide and its selenium-modified product. Natural Product Research, 2025, 21, 1-9.
4. Yingying Shi, Shan Ma, Hanshuo Zhang, Hui Jin, Xuegui Liu*, Pinyi Gao*, Danqi Li*. Systematic Analysis to Explore the Multiple Bioactive Ingredients and Mechanisms of Bupleurum Chinense DC. for Treating Neurodegenerative Diseases. ChemistrySelect, 2025, 10, e202405337.
5. Cong Wang, Lang Qiu, Fang He, Xuegui Liu*, Danqi Li*, Pinyi Gao*. Phytochemical investigation of Rosa laevigata leaves and their chemotaxonomic significance. Biochemical Systematics and Ecology, 2025, 122, 105053.
6. Lang Qiu, Jiayi Wang, Danqi Li*, Xuegui Liu*, Pinyi Gao*, Study on the Synthesis, Structural Characterization and Anti-hepatoma cell proliferation effects of Sulfated Alfalfa Polysaccharides. Journal of Asian Natural Products Research, 2025, 1-18.
7. Yuhan Jin, Yan Cheng, Lingzhi Li, Pinyi Gao*, Danqi Li*, Xuegui Liu*. Quantitative analysis of triterpenoid characteristic components in Rosa laevigata Michx. using HPLC-UV and their potential as neuroprotective bioactive constituents. Accreditation and Quality Assurance, 2025.
8. An-Qi Feng, Zi-Wei Zhao, Chang-Feng Liu, Cheng Du, Pin-Yi Gao*, Xue-Gui Liu*, Dan-Qi Li*. Study on characterization of Bupleurum chinense polysaccharides with antioxidant mechanisms focus on ROS relative signaling pathways and anti-aging evaluation in vivo model. International Journal of Biological Macromolecules, 2024, 266, 131171.
9. Dan-Qi Li, Fan Jiang, Han-Shuo Zhang, Lian-Jun Zheng, Qing-Jie Wang, Ran Fu, Xue-Gui Liu*, Pin-Yi Gao*. Network pharmacology-based approach to investigate the mechanisms of Zingiber officinale Roscoe in the treatment of neurodegenerative diseases. Journal of Food Biochemistry, 2022, 46(5), e14068.
10. Wei Hong, Da Liu, Peng Zhao, Yu-Fei Xi, Rui Guo, Xiao-Xiao Huang, Shao-Jiang Song*, Dan-Qi Li*. UV-guided isolation of enantiomeric polyacetylenes from Bupleurum scorzonerifolium Willd. with inhibitory effects against LPS-induced NO release in BV-2 microglial cells. Bioorganic Chemistry, 2022, 119, 105521.
代表性项目：
1. 辽宁省应用基础研究计划项目“柴胡抗肝癌活性的物质基础与作用机制研究”（2023JH2/101600021，2023.03-2025.03），结题，主持。
2. 辽宁省教育厅科学研究面上项目“南柴胡中抗抑郁活性先导化合物的快速发现及作用机制研究”（LJKZ0438，2021.01-2023.09），结题，主持。
3. 湖北陈孝平科技发展基金会肿瘤防治研究槐耳专项基金项目“槐耳颗粒逆转HER2阳性乳腺癌曲妥珠单抗耐药的分子机制及其临床转化研究”（CXPJJH11800004-009，2019.01-2021.12），结题，主持。
4. 国家自然科学基金青年科学基金项目“柴胡皂苷靶向DDX5逆转HER2阳性乳腺癌曲妥珠单抗耐药的作用机制研究”（81703378，2018.01-2020.12），结题，主持。
5. 辽宁省教育厅一般项目“基于网络药理学的紫花苜蓿皂苷类化学成分抗肝癌的物质基础与作用机理研究”（LQ2017016，2017.12-2020.12），结题，主持。
6. 辽宁省科技厅博士启动基金项目“基于网络药理学的柴胡皂苷逆转HER2阳性乳腺癌耐药的作用机制研究”（20170520250，2017.09-2019.09），结题，主持。
