姓名：张立新
职称：二级教授、博士、硕士生导师
电话：024-89385080
电子邮件：zhanglixin@syuct.edu.cn
教育背景：
1983.09-1987.07 兰州大学，无机化学专业学士学位
1991.09-1993.12 沈阳化工研究院，精细化专业硕士学位
2000.10-2004.04 英国利兹大学，有机化学专业博士学位
工作经历：
1987.08—2000.10 沈阳化工研究院，助理工程师，工程师,高级工程师
2004.02—2004.12 英国利兹大学，化学系博士后
2004.12—2013.04 英国Almac集团,Technical Leader
2013.04—2016.01 中国中化集团公司科技管理部，总经理助理，副总工程师
2016.01—至今 betway中国西汉姆联官网,二级教授，校长特别助理
主要荣誉：
2013 国家海外创新人才计划
2017 辽宁杰出科技工作者
2017 中国第九届“侯德榜化工科学技术奖”成就奖
2018 辽宁省高等学校攀登学者
2019 国务院政府特殊津贴
2025 辽宁省科技进步奖一等奖
研究方向：
1）农药功能分子设计与开发
2）医药功能分子设计与开发研究
3）有机合成方法学研究
代表性成果：（论文、专利等）
论文：
1) Hongyan Pei, Jialin Ye, Dongdong Liu, Yixing Gao, Jing Zhang*, Lixin Zhang*. Synthesis and evaluation of herbicidal ureidopyrimidine compounds: Focus on sulfonamide modifications. J. Agric. Food Chem., 2025, 73(7), 4055-4064.
2) Hongyan Pei, Jialin Ye, Dongdong Liu, Yixing Gao, Jing Zhang*, Lixin Zhang*. Discovery of pyrimidinedione derivatives as potential herbicides: Design, synthesis, and evaluation of herbicidal activity. J. Agric. Food Chem., 2025, 73(35), 21880-21888.
3) Yuandong Liu, Hongyan Pei, Yuxin Huang, Feng Wang, Dongdong Liu, Jing Zhang*, Lixin Zhang*. Advancements in fungicidal chemistry: FM-678-a highly promising fungicidal candidate for combating asian soybean rust. J. Agric. Food Chem., 2025, 73(46), 29593-29603.
4) Dongdong Liu, Jialin Ye, Yixing Gao, Hongyan Pei, Chunfeng Luo, Huan Tian, Juan He, Jing Zhang*, Lixin Zhang*. Design, Synthesis, and Acaricidal/Insecticidal Activities of New Phenylpyrazole Derivatives Comprising an Imide Moiety.J. Agric. Food Chem., 2024, 72(27), 15276-15283.
5) Dongdong Liu, Yixing Gao, Hongyan Pei, Jialin Ye, Haijing Hao, Jing Zhang*, Lixin Zhang*. Unveiling FM-1088: A Breakthrough in Isoindolinone-based Acaricide Development. J. Agric. Food Chem., 2024, 72(32), 18045-18055.
6) Dongdong Liu, Jing Zhang*, Yixing Gao, Haijing Hao, Chenyang Zhang, Feng Wang, Lixin Zhang*. Synthesis, acaricidal activity, and structure–activity relationships of novel phenyl trifluoroethyl thioether derivatives containing substituted benzyl groups. Pest Manag. Sci., 2024, 80(2), 544-553.
7) Jubao Zhou, Siyun Wang, Hu Shi, Hui Jin,* and Lixin Zhang*. Ligand-Free Silver Fluoride-Promoted (3 + 2) Annulation of Oxaziridines and α‑Isocyanoacetates: A Diastereoselective Route to cis-Imidazolines. J. Org. Chem. 2025, 90, 8794−8799.
8) Chen Zhu,‡ Jing Zhang,‡ Jiaxin Yang, Xinxin Li, Xinyu Wang, Hu Shi, Hui Jin,* and Lixin Zhang*. Ketenes as dienophiles in aza-Diels–Alder reactions with dicyanohydrazones for accessing pyridazin-3(2H)-ones. Org. Biomol. Chem. 2025, 23, 6220-6224.
9) Jinfeng Zhang, Chen Zhu, Hu Shi, Hui Jin,* and Lixin Zhang*. N‑Heterocyclic Carbene-Catalyzed [4 + 2] Annulation of Enolizable Thioesters for the Synthesis of 2‑Pyrones. J. Org. Chem. 2025, 90, 6094−6101.
10) Tianxing Li, Xinxin Li, Jinfeng Zhang, Hui Jin* and Lixin Zhang*. Enantioselective Synthesis of 3,4-Dihydropyranones via Low-Loading Squaramide Catalysis “On Water” Adv. Synth. Catal. 2025, 367, e70141.
11) Xinxin Li,† Jun Yang,† Tianxing Li, Chen Zhu, Hui Jin,* and Lixin Zhang*.‘On Water’ Synthesis of Indolyl-Substituted Benzo[b]carbazoles via LiCl-Promoted HBF4-Catalyzed Annulation of ortho-Formylaryl Ketones with Indoles. Synthesis 2025, 57, 2115–2123.
12) Chen Zhu, Jinfeng Zhang, Tianxing Li, Hui Jin* and Lixin Zhang*. Development of aryl 2-pyridinone-fused 2-pyrimidone as a TICT-based turn-off fluorescent probe for ultra-low pH sensing. Dyes and Pigments, 2025, 239, 112795.
13) Jun Yang, Tianxing Li, Hui Jin,* and Lixin Zhang*. Efficient Synthesis of Indolyl Benzo[b]carbazoles via Surfactant-Type Brønsted Acid-Catalyzed Three-Component Cyclization of Ortho-Formylarylketones with Indoles. Eur. J. Org. Chem. 2025, e202401466.
14) Jun Yang,† Jianyu Zhang,† Tianxing Li, Yunting Liu, Hui Jin,* Do Hyun Ryu* and Lixin Zhang*. Lithium Chloride-Promoted Brønsted Acid-Catalyzed Friedel-Crafts Reaction of Indoles with Aldehydes and Ketones "on Water" Adv. Synth. Catal. 2025, 367, e202401542.
15) Jian Liu, Bingfu Wang, Tianxing Li, Hui Jin,* and Lixin Zhang*. Proline-derived dichlorophenyl-substituted urea as catalyst for “on-water” asymmetric addition reactions of oxoindoles to nitroolefins. Tetrahedron Lett. 2024, 143,155117.
16) Zeyao Ji, Xiaochen Wang, Bingfu Wang, Zhen Shan, Hui Jin,* and Lixin Zhang*. On-off Pulsed Ultrasound Promote Asymmetric Noncovalent Organoatalysis “on Water”: An Investigation in Michael Addition and Diels-Alder Reactions. Adv. Synth. Catal. 2024, 366（14）, 3194-3202.
17) Bingfu Wang, Jian Liu, Hui Jin,* and Lixin Zhang*. Organocatalytic Enantioselective Synthesis of Nitrocyclopropanes Bearing a Thioester Group and Three Stereogenic Centers. Adv. Synth. Catal. 2024, 366（12）, 2742-2748.
18) Bingfu Wang, Jian Liu, Tianxing Li, Hui Jin,* and Lixin Zhang*. Asymmetric synthesis of (R)-baclofen and (3S,4S)-tetflupyrolimet via “on water” organocatalytic addition reactions: a tip on catalysts screening Org. Biomol. Chem. 2024, 22, 1146-1151.
19) Chen Zhu, Jubao Zhou, Xinxin Li, Xinyu Wang, Hui Jin*, Lixin Zhang*. “Clip-cycle” synthesis of 2-pyridazinones bearing enaminonitrile moiety from thioesters and dicyanohydrazones. Tetrahedron Lett. 2024, 135, 154905.
20) Bingfu Wang, Tianxing Li, Jian Liu, Shuo Wang, Hu Shi, Hui Jin,* Do Hyun Ryu*and Lixin Zhang*. Pentafluorophenyl-Substituted Proline-Derived Chiral Urea for “On Water” Asymmetric Hydrogen-Bonding Catalysis Adv. Synth. Catal. 2023, 365, 4155– 4162.
专利：
1. ZHANG Lixin, ZHANG Jing, ZHANG Xihan, GAO Yixin, WANG Jie, KANG Zhuo. Benzamide compound and use thereof, 印度尼西亚国家发明型专利, P00202009707, 2025.09.03授权。
2. ZHANG Lixin, ZHANG Jing, GAO Yixing, KANG Zhuo. Isoxazoline compounds and use thereof, 美国国家发明型专利, US12371410B2, 2025.07.29授权。
3. ZHANG Lixin, ZHANG Jing, GAO Yixing, KANG Zhuo. Isoxazoline compounds, their preparation methods and use, 美国国家发明型专利, US17597225, 2025.02.20授权。
4. ZHANG Lixin, ZHANG Jing, PEI Hongyan, WANG Jie, SHENG Zhubo, KANG Zhuo. Isophthalamide compound and use thereof, 美国国家发明型专利, US17638743, 2025.09.17授权。
5. ZHANG Lixin, ZHANG Jing, PEI Hongyan, WANG Jie, SHENG Zhubo, KANG Zhuo. Isophthalamide compound and use thereof, 美国国家发明型专利, US17638724, 2025.07.08授权。
6. ZHANG Lixin, ZHANG Jing, GAO Yixing, KANG Zhuo. Biphenyl compound containing sulfide (sulfoxide) substitution and use thereof, 澳大利亚国家发明型专利, AU2022216691B2, 2025.01.16授权。
7. ZHANG Lixin, ZHANG Jing, GAO Yixing, KANG Zhuo. Biphenyl compound containing sulfide (sulfoxide) substitution and use thereof, 加拿大国家发明型专利, CA3207587, 2025.02.20授权。
8. 张立新、张静、裴鸿艳、康卓. 一种酰胺类化合物及其用途，中国国家发明型专利，ZL202210800664.0；2025.03.25授权。
9. ZHANG Lixin, ZHANG Jing, PEI Hongyan, KANG Zhuo. Amide compound and use thereof, 澳大利亚国家发明型专利, AU2022310062, 2025.01.30授权。
10. 张立新、张静、高一星、刘东东、康卓. 三氟乙基硫醚（亚砜）取代苯类化合物的制备方法及其中间体，中国国家发明型专利，ZL202210856313.1，2025.03.25授权。
11. 张立新、王锋、张静、裴鸿艳、康卓. 一种噁二唑类化合物及其应用，中国国家发明型专利，ZL202310078639.0，2025.09.05授权。
12. 张立新、王锋、张静、裴鸿艳、康卓. 一种噁二唑类化合物及其用途，中国国家发明型专利，ZL202310079272.4，2025.09.05授权。
代表性项目：
1. 沈阳市科技创新“双百工程”项目“基于群体感应系统的细菌抑制剂的研制”（Y17-0-001，2017-2019），主持。
2. 沈阳市科技局第四批科技补助项目“辽宁省绿色功能分子设计与开发重点实验室建设”（2017-2020），主持。
3. 广西重点研发计划项目“水稻和柑橘高效低风险细菌抑制剂的研发与应用”（桂科AB1850015，2019-2022），主持。
4. 沈阳市靶向农药重点实验室项目（2019-2021），主持。
5. 沈阳市科技局第四批科技补助项目“硼镁资源开发与精细化工技术国家地方联合工程实验室”（2017-2020），主持。
6. 沈阳市发改委补助项目“硼镁资源开发与精细化工技术国家地方联合工程实验室”（2017-2020），主持。
7. 辽宁省教育厅攀登学者项目（2018-2020），主持。
8. 南宁市科技重大专项“柑橘难防治病虫害新药剂研究与开发”（20185207，25万元，2018-2022），主持。
9. 国家自然科学基金面上项目“双酰胺类杀虫剂对昆虫和鱼类GABA受体选择性作用机制与结构优化研究”（22277081，2023.01-2026.12），主持。
10. 企业横向课题“苯甲酰胺类新农药研究与开发（2022210101001209，2022.04-2027.04），主持。
